Benzylidene-bis-(4-Hydroxycoumarin) and Benzopyrano-Coumarin Derivatives: Synthesis, 1H/13C-NMR Conformational and X-ray Crystal Structure Studies and In Vitro Antiviral Activity Evaluations

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Završnik, Davorka ; Muratović, Samija ; Makuc, Damjan ; Plavec, Janez ; Cetina, Mario ; Nagl, Ante ; Clercq, Erik De ; Balzarini, Jan ; Mintas, Mladen (2011)
  • Publisher: Molecular Diversity Preservation International
  • Journal: Molecules (issn: 1420-3049)
  • Related identifiers: doi: 10.3390/molecules16076023
  • Subject: 4-hydroxycoumarin | 1H/13C-NMR conformational study | X-ray diffraction | Organic chemistry | QD241-441 | <sup>1</sup>H/<sup>13</sup>C-NMR conformational study | antiviral activity | benzopyranocoumarin

We report on the synthesis of 4-hydroxycoumarin dimers 1-15 bearing an aryl substituent on the central linker and fused benzopyranocoumarin derivatives 16-20 and on their in vitro broad anti-DNA and RNA virus activity evaluations. The chemical identities and structure o... View more
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