Transformation of an Unclassified Myeloproliferative Neoplasm with a Rare BCR-JAK2 Fusion Transcript Resulting from the Translocation (9;22)(p24;q11)

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Chamseddine, A. N. ; Etancelin, P. ; Penther, D. ; Parmentier, F. ; Kuadjovi, C. ; Camus, V. ; Contentin, N. ; Lenain, P. ; Bastard, C. ; Tilly, H. ; Jardin, F. (2015)
  • Publisher: Hindawi Publishing Corporation
  • Journal: Case Reports in Hematology, volume 2,015 (issn: 2090-6560, eissn: 2090-6579)
  • Related identifiers: pmc: PMC4348613, doi: 10.1155/2015/252537
  • Subject: Diseases of the blood and blood-forming organs | Case Report | RC633-647.5 | Article Subject
    mesheuropmc: food and beverages | hemic and lymphatic diseases

BCR-ABL1 negative myeloproliferative neoplasms (MPNs) are known to contain alterations of the tyrosine kinase JAK2 (located on 9p24) that result in constitutive activation of the encoded protein. JAK2 fusions are reported in acute and chronic leukemias of myeloid and ly... View more
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