publication . Article . Other literature type . 2014

PARPi-FL - a Fluorescent PARP1 Inhibitor for Glioblastoma Imaging

Thomas Reiner; Wolfgang A. Weber; Christian Brand; Beatriz Salinas; Christopher Irwin; Yasiri Portorreal; Pooja Desai; Yachao Zhang;
Open Access English
  • Published: 01 May 2014 Journal: Neoplasia, issue 5, pages 432-440 (issn: 14765586, Copyright policy)
  • Publisher: Neoplasia Press, Inc. Published by Elsevier Inc.
AbstractNew intravital optical imaging technologies have revolutionized our understanding of mammalian biology and continue to evolve rapidly. However, there are only a limited number of imaging probes available to date. In this study, we investigated in mouse models of glioblastoma whether a fluorescent small molecule inhibitor of the DNA repair enzyme PARP1, PARPi-FL, can be used as an imaging agent to detect glioblastomas in vivo. We demonstrated that PARPi-FL has appropriate biophysical properties, low toxicity at concentrations used for imaging, high stability in vivo, and accumulates selectively in glioblastomas due to high PARP1 expression. Importantly, s...
free text keywords: Cancer Research, Article, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cell culture, DNA repair, Small molecule, PARP1, In vivo, Imaging agent, Poly ADP ribose polymerase, Neuroimaging, Biology, Pathology, medicine.medical_specialty, medicine
Related Organizations
Funded by
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
NIH| Bioorthogonal Strategies for Targeted PET Imaging Probe Development
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1K25EB016673-01
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