Mitochondrial GTP Regulates Glucose-Stimulated Insulin Secretion

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Kibbey, Richard G; Pongratz, Rebecca L; Romanelli, Anthony J; Wollheim, Claes; Cline, Gary W; Shulman, Gerald I;
  • Publisher: Elsevier BV
  • Journal: Cell Metabolism,volume 5,issue 4,pages253-264 (issn: 1550-4131)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.cmet.2007.02.008
  • Subject: Energy Metabolism/physiology | Molecular Biology | Insulin/secretion | Physiology | Mitochondria/chemistry/drug effects | RNA, Small Interfering/pharmacology | Models, Biological | Succinate-CoA Ligases/antagonists & inhibitors/genetics | Guanosine Triphosphate/analysis/physiology | Cell Biology | Calcium/metabolism | Cells, Cultured | Oxidation-Reduction | Animals | Rats | Glucose/pharmacology | Rats, Sprague-Dawley | Insulin-Secreting Cells/drug effects/secretion
    • ddc: ddc:612
    mesheuropmc: endocrine system

Nucleotide-specific isoforms of the tricarboxylic acid (TCA) cycle enzyme succinyl-CoA synthetase (SCS) catalyze substrate-level synthesis of mitochondrial GTP (mtGTP) and ATP (mtATP). While mtATP yield from glucose metabolism is coupled with oxidative phosphorylation a... View more
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