Etude par génétique inverse du gène codant la protéine TARGET OF RAPAMYCIN d'Arabidopsis thaliana (AtTOR), l'homologue d'une kinase contrôlant la croissance cellulaire chez les eucaryotes

Doctoral thesis French OPEN
Menand, Benoit;
  • Publisher: HAL CCSD
  • Subject: [SDV.BV]Life Sciences [q-bio]/Vegetal Biology | rapamycine | [ SDV.BV ] Life Sciences [q-bio]/Vegetal Biology | plante | cycle cellulaire Arabidopsis thaliana | meristeme | croissance

TOR (target of rapamycin) protein kinases were identified in yeast, mammals and Drosophila as central controllers of cell growth. Thu, G1 to S phases progression through the cell cycle is blocked by rapamycin, a drug which specifically inhibits TOR activity by forming a... View more
  • References (248)
    248 references, page 1 of 25

    Alarcon, C. M., Cardenas, M. E. et Heitman, J. (1996) Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast. Genes Dev. 10, 279-288.

    Alarcon, C. M., Heitman, J. et Cardenas, M. E. (1999) Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast. Mol. Biol. Cell 10, 2531-2546.

    Albig, A. R. et Decker, C. J. (2001) The target of rapamycin signaling pathway regulates mRNA turnover in the yeast Saccharomyces cerevisiae. Mol. Biol. Cell 12, 3428-3438.

    Altmann, M., Schmitz, N., Berset, C. et Trachsel, H. (1997) A novel inhibitor of cap-dependent translation initiation in yeast: p20 competes with eIF4G for binding to eIF4E. EMBO J. 16:1114-1121.

    Altschul, S. F., Gish, W., Miller, W., Myers, E. W. et Lipman, D. J. (1990) Basic local alignment search tool. J. Mol. Biol. 215, 403-410.

    An,Y. Q., McDowell, J. M., Huang, S., McKinney, E. C., Chambliss, S. et Meagher, R. B. (1996) Strong, constitutive expression of the Arabidopsis ACT2/ACT8 actin subclass in vegetative tissues. Plant J. 10 (1), 107-121.

    Andrade, M. A. et Bork, P. (1995) HEAT repeats in the Huntington's disease protein. Nat. Genet. 11, 115-116.

    Andrade, M. A., Ponting, C. P., Gibson, T. J. et Bork, P. (2000) Homology-based method for identification of protein repeats using statistical significance estimates. J. Mol. Biol. 298, 521- 537.

    The Arabidopsis initiative. (2000) Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408, 796-815.

    Arndt, C., Cruz, M.C., Cardenas, M. E. et Heitman, J. (1999) Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans. Microbiology 145, 1989-2000.

  • Metrics
Share - Bookmark