Exposing asymmetric gray matter vulnerability in amyotrophic lateral sclerosis

Article English OPEN
Matthew S. Devine; Kerstin Pannek; Alan Coulthard; Pamela A. McCombe; Stephen E. Rose; Robert D. Henderson;
  • Publisher: Elsevier
  • Journal: NeuroImage: Clinical,volume 7,pages782-787 (issn: 2213-1582, eissn: 2213-1582)
  • Related identifiers: pmc: PMC4375643, doi: 10.1016/j.nicl.2015.03.006
  • Subject: R858-859.7 | Motor neuron disease | Computer applications to medicine. Medical informatics | Neurology. Diseases of the nervous system | ALS, amyotrophic lateral sclerosis | RC346-429 | Voxel-based morphometry | Asymmetry | LMN, lower motor neuron | Amyotrophic lateral sclerosis | Limb dominance | Regular Article | VBM, voxel-based morphometry | UMN, upper motor neuron | GM, gray matter

Limb weakness in amyotrophic lateral sclerosis (ALS) is typically asymmetric. Previous studies have identified an effect of limb dominance on onset and spread of weakness, however relative atrophy of dominant and non-dominant brain regions has not been investigated. Our... View more
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