publication . Article . Other literature type . 2009

Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord

Ukita, Kanako; Hirahara, Shino; Oshima, Naoko; Imuta, Yu; Yoshimoto, Aki; Jang, Chuan-Wei; Oginuma, Masayuki; Saga, Yumiko; Behringer, Richard R.; Kondoh, Hisato; ...
Open Access English
  • Published: 01 Oct 2009 Journal: Mechanisms of Development, volume 126, issue 10, pages 791-803 (issn: 0925-4773, Copyright policy)
  • Publisher: Elsevier BV
Abstract
The notochord develops from notochord progenitor cells (NPCs) and functions as a major signaling center to regulate trunk and tail development. NPCs are initially specified in the node by Wnt and Nodal signals at the gastrula stage. However, the underlying mechanism that maintains the NPCs throughout embryogenesis to contribute to the posterior extension of the notochord remains unclear. Here, we demonstrate that Wnt signaling in the NPCs is essential for posterior extension of the notochord. Genetic labeling revealed that the Noto-expressing cells in the ventral node contribute the NPCs that reside in the tail bud. Robust Wnt signaling in the NPCs was observed ...
Subjects
mesheuropmc: embryonic structuresfungiotorhinolaryngologic diseasesanimal structuresstomatognathic diseases
free text keywords: Developmental Biology, Embryology, Article
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publication . Article . Other literature type . 2009

Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord

Ukita, Kanako; Hirahara, Shino; Oshima, Naoko; Imuta, Yu; Yoshimoto, Aki; Jang, Chuan-Wei; Oginuma, Masayuki; Saga, Yumiko; Behringer, Richard R.; Kondoh, Hisato; ...