Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord

Article, Other literature type English OPEN
Ukita, Kanako; Hirahara, Shino; Oshima, Naoko; Imuta, Yu; Yoshimoto, Aki; Jang, Chuan-Wei; Oginuma, Masayuki; Saga, Yumiko; Behringer, Richard R.; Kondoh, Hisato; Sasaki, Hiroshi;
  • Publisher: Elsevier BV
  • Journal: Mechanisms of Development,volume 126,issue 10,pages791-803 (issn: 0925-4773)
  • Related identifiers: pmc: PMC2757446, doi: 10.1016/j.mod.2009.08.003
  • Subject: Developmental Biology | Embryology | Article
    mesheuropmc: embryonic structures | fungi | otorhinolaryngologic diseases | animal structures | stomatognathic diseases

The notochord develops from notochord progenitor cells (NPCs) and functions as a major signaling center to regulate trunk and tail development. NPCs are initially specified in the node by Wnt and Nodal signals at the gastrula stage. However, the underlying mechanism tha... View more
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