Predicting dementia using socio-demographic characteristics and the Free and Cued Selective Reminding Test in the general population

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Mura , Thibault ; Baramova , Marieta ; Gabelle , Audrey ; Artero , Sylvaine ; Dartigues , Jean-François ; Amieva , Hélène ; Berr , Claudine (2016)
  • Publisher: BioMed Central
  • Journal: Alzheimer's Research & Therapy, volume 9 (issn: 1758-9193, eissn: 1758-9193)
  • Related identifiers: doi: 10.1186/s13195-016-0230-x, doi: 10.13039/501100002915, pmc: PMC5364571
  • Subject: Alzheimer disease | [ SDV ] Life Sciences [q-bio] | preclinical Alzheimer disease | Early clinical trial | Prediction | Clinical Neurology | Dementia | prodromal Alzheimer disease | Cognitive Neuroscience | Research | Neurology

Background Our study aimed to determine whether the consideration of socio-demographic features improves the prediction of Alzheimer’s dementia (AD) at 5 years when using the Free and Cued Selective Reminding Test (FCSRT) in the general older population. Methods Our analyses focused on 2558 subjects from the prospective Three-City Study, a cohort of community-dwelling individuals aged 65 years and over, with FCSRT scores. Four “residual scores” and “risk scores” were built that included the FCSRT scores and socio-demographic variables. The predictive performance of crude, residual and risk scores was analyzed by comparing the areas under the ROC curve (AUC). Results In total, 1750 subjects were seen 5 years after completing the FCSRT. AD was diagnosed in 116 of them. Compared with the crude free-recall score, the predictive performances of the residual score and of the risk score were not significantly improved (AUC: 0.83 vs 0.82 and 0.88 vs 0.89 respectively). Conclusion Using socio-demographic features in addition to the FCSRT does not improve its predictive performance for dementia or AD. Electronic supplementary material The online version of this article (doi:10.1186/s13195-016-0230-x) contains supplementary material, which is available to authorized users.
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