Activation of Salmonella Typhi-Specific Regulatory T Cells in Typhoid Disease in a Wild-Type S. Typhi Challenge Model

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McArthur, MA; Fresnay, S; Magder, LS; Darton, TC; Jones, C; Waddington, CS; Blohmke, CJ; Dougan, G; Angus, B; Levine, MM; Pollard, AJ; Sztein, MB;

Salmonella Typhi (S. Typhi), the causative agent of typhoid fever, causes significant morbidity and mortality worldwide. Currently available vaccines are moderately efficacious, and identification of immunological responses associated with protection or disease will fac... View more