Exploring the complexity of the HIV-1 fitness landscape.

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Kouyos, Roger D.; Leventhal, Gabriel E.; Hinkley, Trevor; Haddad, Mojgan; Whitcomb, Jeannette M.; Petropoulos, Christos J.; Bonhoeffer, Sebastian;

Although fitness landscapes are central to evolutionary theory, so far no biologically realistic examples for large-scale fitness landscapes have been described. Most currently available biological examples are restricted to very few loci or alleles and therefore do not... View more