publication . Article . 2014

Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity

Łuczyński, Włodzimierz; Fendler, Wojciech; Ramatowska, Anna; Szypowska, Agnieszka; Szadkowska, Agnieszka; Młynarski, Wojciech; Chumiecki, Miron; Jarosz-Chobot, Przemysława; Chrzanowska, Joanna; Noczyńska, Anna; ...
Open Access English
  • Published: 01 Aug 2014 Journal: International Journal of Endocrinology, volume 2,014 (issn: 1687-8337, eissn: 1687-8345, Copyright policy)
  • Publisher: Hindawi Publishing Corporation
Abstract
The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4–18 years) were qualified to take part in the study. All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36. Results. Variants of FTO showed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P = 0.0003), poor metabolic control (P = 0.0001), and carriage of the A allele of the FTO rs9939609 gene (P = 0.02). Conclusion. Our ...
Subjects
mesheuropmc: nutritional and metabolic diseasesendocrine system diseases
free text keywords: Research Article, RC648-665, Diseases of the endocrine glands. Clinical endocrinology, Article Subject
18 references, page 1 of 2

Chrzanowska, M, Koziel, S, Ulijaszek, SJ. Changes in BMI and the prevalence of overweight and obesity in children and adolescents in Cracow, Poland, 1971–2000. Economics & Human Biology . 2007; 5 (3): 370-378 [PubMed] []

Frayling, TM, Timpson, NJ, Weedon, MN. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science . 2007; 316 (5826): 889-894 [OpenAIRE] [PubMed] []

Cecil, J, Dalton, M, Finlayson, G, Blundell, J, Hetherington, M, Palmer, C. Obesity and eating behaviour in children and adolescents: contribution of common gene polymorphisms. International Review of Psychiatry . 2012; 24 (3): 200-210 [PubMed] []

Malzahn, D, Müller-Nurasyid, M, Heid, IM, Wichmann, HE, The KORA Study Group6, null, Bickeböller, H. Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R. European Journal of Human Genetics . 2014

Steigleder-Schweiger, C, Rami-Merhar, B, Waldhör, T. Prevalence of cardiovascular risk factors in children and adolescents with type 1 diabetes in Austria. European Journal of Pediatrics . 2012; 171 (8): 1193-1202 [PubMed] []

Krishnan, S, Fields, DA, Copeland, KC, Blackett, PR, Anderson, MP, Gardner, AW. Sex differences in cardiovascular disease risk in adolescents with type 1 diabetes. Gender Medicine . 2012; 9 (4): 251-258 [OpenAIRE] [PubMed] []

Mortensen, HB, Hougaard, P, Swift, P. New definition for the partial remission period in children and adolescents with type 1 diabetes. Diabetes Care . 2009; 32 (8): 1384-1390 [OpenAIRE] [PubMed] []

Kułaga, Z, Litwin, M, Tkaczyk, M. Polish 2010 growth references for school-aged children and adolescents. European Journal of Pediatrics . 2011; 170 (5): 599-609 [OpenAIRE] [PubMed]

Bland, JM, Altman, DG. Statistical methods for assessing agreement between two methods of clinical measurement. The Lancet . 1986; 1 (8476): 307-310 []

Pyrzak, B, Wisniewska, A, Majcher, A, Tysarowski, A, Demkow, U. Relation of fat-mass and obesity-associated gene polymorphism to fat mass content and body mass index in obese children. Advances in Experimental Medicine and Biology . 2013; 756: 255-262 [PubMed] []

Luczynski, W, Zalewski, G, Bossowski, A. The association of the FTO rs9939609 polymorphism with obesity and metabolic risk factors for cardiovascular diseases in polish children. Journal of Physiology and Pharmacology . 2012; 63 (3): 241-248 [PubMed] []

Field, SF, Howson, JMM, Walker, NM, Dunger, DB, Todd, JA. Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls. Diabetologia . 2007; 50 (10): 2218-2220 [OpenAIRE] [PubMed] []

Winkler, C, Raab, J, Grallert, H, Ziegler, A. Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes. PloS ONE . 2012; 7 (4) [] []

Gu, HF, Alvarsson, A, Brismar, K. The common FTO genetic polymorphism rs9939609 is associated with increased BMI in type 1 diabetes but not with diabetic nephropathy. Biomarker Insights . 2010; 5: 29-32 [OpenAIRE] [PubMed] []

Zhao, J, Bradfield, JP, Li, M. The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity . 2009; 17 (12): 2254-2257 [OpenAIRE] [PubMed] []

18 references, page 1 of 2
Abstract
The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4–18 years) were qualified to take part in the study. All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36. Results. Variants of FTO showed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P = 0.0003), poor metabolic control (P = 0.0001), and carriage of the A allele of the FTO rs9939609 gene (P = 0.02). Conclusion. Our ...
Subjects
mesheuropmc: nutritional and metabolic diseasesendocrine system diseases
free text keywords: Research Article, RC648-665, Diseases of the endocrine glands. Clinical endocrinology, Article Subject
18 references, page 1 of 2

Chrzanowska, M, Koziel, S, Ulijaszek, SJ. Changes in BMI and the prevalence of overweight and obesity in children and adolescents in Cracow, Poland, 1971–2000. Economics & Human Biology . 2007; 5 (3): 370-378 [PubMed] []

Frayling, TM, Timpson, NJ, Weedon, MN. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science . 2007; 316 (5826): 889-894 [OpenAIRE] [PubMed] []

Cecil, J, Dalton, M, Finlayson, G, Blundell, J, Hetherington, M, Palmer, C. Obesity and eating behaviour in children and adolescents: contribution of common gene polymorphisms. International Review of Psychiatry . 2012; 24 (3): 200-210 [PubMed] []

Malzahn, D, Müller-Nurasyid, M, Heid, IM, Wichmann, HE, The KORA Study Group6, null, Bickeböller, H. Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R. European Journal of Human Genetics . 2014

Steigleder-Schweiger, C, Rami-Merhar, B, Waldhör, T. Prevalence of cardiovascular risk factors in children and adolescents with type 1 diabetes in Austria. European Journal of Pediatrics . 2012; 171 (8): 1193-1202 [PubMed] []

Krishnan, S, Fields, DA, Copeland, KC, Blackett, PR, Anderson, MP, Gardner, AW. Sex differences in cardiovascular disease risk in adolescents with type 1 diabetes. Gender Medicine . 2012; 9 (4): 251-258 [OpenAIRE] [PubMed] []

Mortensen, HB, Hougaard, P, Swift, P. New definition for the partial remission period in children and adolescents with type 1 diabetes. Diabetes Care . 2009; 32 (8): 1384-1390 [OpenAIRE] [PubMed] []

Kułaga, Z, Litwin, M, Tkaczyk, M. Polish 2010 growth references for school-aged children and adolescents. European Journal of Pediatrics . 2011; 170 (5): 599-609 [OpenAIRE] [PubMed]

Bland, JM, Altman, DG. Statistical methods for assessing agreement between two methods of clinical measurement. The Lancet . 1986; 1 (8476): 307-310 []

Pyrzak, B, Wisniewska, A, Majcher, A, Tysarowski, A, Demkow, U. Relation of fat-mass and obesity-associated gene polymorphism to fat mass content and body mass index in obese children. Advances in Experimental Medicine and Biology . 2013; 756: 255-262 [PubMed] []

Luczynski, W, Zalewski, G, Bossowski, A. The association of the FTO rs9939609 polymorphism with obesity and metabolic risk factors for cardiovascular diseases in polish children. Journal of Physiology and Pharmacology . 2012; 63 (3): 241-248 [PubMed] []

Field, SF, Howson, JMM, Walker, NM, Dunger, DB, Todd, JA. Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls. Diabetologia . 2007; 50 (10): 2218-2220 [OpenAIRE] [PubMed] []

Winkler, C, Raab, J, Grallert, H, Ziegler, A. Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes. PloS ONE . 2012; 7 (4) [] []

Gu, HF, Alvarsson, A, Brismar, K. The common FTO genetic polymorphism rs9939609 is associated with increased BMI in type 1 diabetes but not with diabetic nephropathy. Biomarker Insights . 2010; 5: 29-32 [OpenAIRE] [PubMed] []

Zhao, J, Bradfield, JP, Li, M. The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity . 2009; 17 (12): 2254-2257 [OpenAIRE] [PubMed] []

18 references, page 1 of 2
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publication . Article . 2014

Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity

Łuczyński, Włodzimierz; Fendler, Wojciech; Ramatowska, Anna; Szypowska, Agnieszka; Szadkowska, Agnieszka; Młynarski, Wojciech; Chumiecki, Miron; Jarosz-Chobot, Przemysława; Chrzanowska, Joanna; Noczyńska, Anna; ...