miREM: an expectation-maximization approach for prioritizing miRNAs associated with gene-set

Article English OPEN
Luqman Hakim Abdul Hadi; Quy Xiao Xuan Lin; Tri Tran Minh; Marie Loh; Hong Kiat Ng; Agus Salim; Richie Soong; Touati Benoukraf;
  • Publisher: BMC
  • Journal: BMC Bioinformatics,volume 19 (issn: 1471-2105, eissn: 1471-2105)
  • Related identifiers: pmc: PMC6086043, doi: 10.1186/s12859-018-2292-1
  • Subject: R858-859.7 | Computer applications to medicine. Medical informatics | Software | Gene regulation | miRNA | Expectation-maximization | Biology (General) | QH301-705.5

Background The knowledge of miRNAs regulating the expression of sets of mRNAs has led to novel insights into numerous and diverse cellular mechanisms. While a single miRNA may regulate many genes, one gene can be regulated by multiple miRNAs, presenting a complex relati... View more
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