Subject: Research Article | Neurology. Diseases of the nervous system | RC346-429 | Article Subject
The human neuroblastoma SH-SY5Y cell line has been used as a dopaminergic cell model for Parkinson's disease research. Whether undifferentiated or differentiated SH-SY5Y cells are more suitable remains controversial. This study aims to evaluate the expression of apoptos... View more
Korecka, J. A., van Kesteren, R. E., Blaas, E., Spitzer, S. O., Kamstra, J. H., Smit, A. B., Swaab, D. F., Verhaagen, J., Bossers, K.. Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling.
PLoS ONE. 2013; 8 (5)
Cheung, Y.-T., Lau, W. K.-W., Yu, M.-S., Lai, C. S.-W., Yeung, S.-C., So, K.-F., Chang, R. C.-C.. Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research.
NeuroToxicology. 2009; 30 (1): 127-135
Lopes, F. M., Schröder, R., Júnior, M. L. C. D. F., Zanotto-Filho, A., Müller, C. B., Pires, A. S., Meurer, R. T., Colpo, G. D., Gelain, D. P., Kapczinski, F., Moreira, J. C. F., Fernandes, M. D. C., Klamt, F.. Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies.
Brain Research. 2010; 1337: 85-94
Itano, Y., Nomura, Y.. 1-methyl-4-phenyl-pyridinium ion (MPP+) causes DNA fragmentation and increases the Bcl-2 expression in human neuroblastoma, SH-SY5Y cells, through different mechanisms.
Brain Research. 1995; 704 (2): 240-245
Dennis, J., Bennett, J. P.. Interactions among nitric oxide and Bcl-family proteins after MPP+ exposure of SH-SY5Y neural cells I: MPP+ increases mitochondrial NO and Bax protein.
Journal of Neuroscience Research. 2003; 72 (1): 76-88
Wang, X.-J., Xu, J.-X.. Salvianic acid A protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.
Neuroscience Research. 2005; 51 (2): 129-138
Doo, A.-R., Kim, S.-N., Kim, S.-T., Park, J.-Y., Chung, S.-H., Choe, B.-Y., Chae, Y., Lee, H., Yin, C.-S., Park, H.-J.. Bee venom protects SH-SY5Y human neuroblastoma cells from 1-methyl-4-phenylpyridinium-induced apoptotic cell death.
Brain Research. 2012; 1429: 106-115
Luchtman, D. W., Meng, Q., Wang, X., Shao, D., Song, C.. Omega-3 fatty acid eicospentaenoic acid attenuates MPP+-induced neurodegeneration in fully differentiated human SH-SY5Y and primary mesencephalic cells.
Journal of Neurochemistry. 2013; 124 (6): 855-868
Wang, Y., Gao, J., Miao, Y., Cui, Q., Zhao, W., Zhang, J., Wang, H.. Pinocembrin protects SH-SY5Y cells against MPP+-induced neurotoxicity through the mitochondrial apoptotic pathway.
Journal of Molecular Neuroscience. 2014; 53 (4): 537-545