publication . Other literature type . Article . 2015

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

Maria Laura Martin; Enrico Velardi; Margaret O'Connor; Kevin P. O’Rourke; Shuichiro Takashima; Lukas E. Dow; Gillian Lawrence; Odette M. Smith; Edward E. S. Nieuwenhuis; Yuan-Hung Lo; ...
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Open Access
  • Published: 01 Dec 2015
  • Publisher: Springer Science and Business Media LLC
Abstract
Epithelial regeneration is critical for barrier maintenance and organ function after intestinal injury. The intestinal stem cell (ISC) niche provides Wnt, Notch, and epidermal growth factor (EGF) signals supporting Lgr5+ crypt base columnar ISCs for normal epithelial maintenance1,2. However, little is known about the regulation of the ISC compartment after tissue damage. Utilizing ex vivo organoid cultures, we provide evidence that innate lymphoid cells (ILCs), potent producers of Interleukin-22 (IL-22) after intestinal injury3,4, increased the growth of murine small intestine (SI) organoids in an IL-22-dependent fashion. Recombinant IL-22 directly targeted ISCs...
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doi: 10.1038/nature16460
handle: 1765/84635
pmc: PMC4720437
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Subjects
Medical Subject Headings: digestive systeminorganic chemicals
free text keywords: Article, Multidisciplinary, Epidermal growth factor, Immunology, Stem cell, Innate lymphoid cell, Interleukin 22, Cell biology, Intestinal mucosa, Intestinal epithelium, Organoid, Paneth cell, medicine.anatomical_structure, medicine, Biology
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Funded by
NIH| Strategies to Enhance Lymphoid Recovery After Radiation-Induced Injury
Project
Strategies to Enhance Lymphoid Recovery After Radiation-Induced Injury
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AI080455-02
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
, NIH| Investigating the role of interleukin-22 in thymus function
Project
Investigating the role of interleukin-22 in thymus function
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1K99CA176376-01
  • Funding stream: NATIONAL CANCER INSTITUTE
, NIH| Regulation of the intestinal stem cell compartment after hematopoietic transplantation
Project
Regulation of the intestinal stem cell compartment after hematopoietic transplantation
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL125571-03
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
, EC| STROMA
Project
STROMA
Stromal Cell- Immune Cell Interactions in Health and Disease
  • Funder: European Commission (EC)
  • Project Code: 289720
  • Funding stream: FP7 | SP3 | PEOPLE
, NIH| Strategies to enhance immune reconstitution after bone marrow transplant
Project
Strategies to enhance immune reconstitution after bone marrow transplant
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL069929-12
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
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