Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition

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Tse, Anfernee Kai-Wing; Chen, Ying-Jie; Fu, Xiu-Qiong; Su, Tao; Li, Ting; Guo, Hui; Zhu, Pei-Li; Kwan, Hiu-Yee; Cheng, Brian Chi-Yan; Cao, Hui-Hui; Lee, Sally Kin-Wah; Fong, Wang-Fun; Yu, Zhi-Ling;
(2017)
  • Publisher: Elsevier
  • Journal: Redox Biology,volume 11,pages562-576 (issn: 2213-2317, eissn: 2213-2317)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5247288, doi: 10.1016/j.redox.2017.01.010
  • Subject: NF-κB, Nuclear factor kappa B | R5-920 | Melanoma | ICL, DNA interstrand crosslink | QH301-705.5 | BRAF, serine/threonine-protein kinase B-Raf | NAC, N-acetyl cysteine | IKKβ, Inhibitor of nuclear factor kappa-B kinase subunit beta | ROS, Reactive oxygen species | Reactive oxygen species | Medicine (General) | IKKβ | Nitrosourea | Research Paper | Biology (General)
    mesheuropmc: otorhinolaryngologic diseases | sense organs | body regions | neoplasms | organic chemicals

Nitrosourea represents one of the most active classes of chemotherapeutic alkylating agents for metastatic melanoma. Treatment with nitrosoureas caused severe systemic side effects which hamper its clinical use. Here, we provide pharmacological evidence that reactive ox... View more
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