Subject: Biochemistry, Genetics and Molecular Biology(all) | Article
mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalities | musculoskeletal diseases
The lack of appropriate animal models has hampered efforts to develop therapies for Duchenne muscular dystrophy (DMD). A new mouse model lacking both dystrophin and telomerase (Sacco et al., 2010) closely mimics the pathological progression of human DMD and shows that muscle stem cell activity is a key determinant of disease severity.