CTCF Mediates the Cell-Type Specific Spatial Organization of the Kcnq5 Locus and the Local Gene Regulation

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Ren, Licheng ; Wang, Yang ; Shi, Minglei ; Wang, Xiaoning ; Yang, Zhong ; Zhao, Zhihu (2012)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 7, issue 2 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0031416, pmc: PMC3275579
  • Subject: Q | R | Research Article | Biology | Genetics | Molecular Cell Biology | Science | Genomics | Medicine

Chromatin loops play important roles in the dynamic spatial organization of genes in the nucleus. Growing evidence has revealed that the multivalent functional zinc finger protein CCCTC-binding factor (CTCF) is a master regulator of genome spatial organization, and medi... View more
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