Inhibition of the ATP Synthase Eliminates the Intrinsic Resistance of Staphylococcus aureus towards Polymyxins

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Vestergaard, Martin; Nøhr-Meldgaard, Katrine; Bojer, Martin Saxtorph; Krogsgård Nielsen, Christina; Meyer, Rikke Louise; Slavetinsky, Christoph; Peschel, Andreas; Ingmer, Hanne;
  • Publisher: American Society for Microbiology
  • Journal: volume 8,issue 5issn: 2161-2129, eissn: 2150-7511
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1128/mBio.01114-17, pmc: PMC5587909
  • Subject: polymyxin | Research Article | /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 | intrinsic resistance | Microbiology | atpA | QR1-502 | Journal Article | ATP synthase | oligomycin A | antimicrobial peptides | Staphylococcus aureus
    mesheuropmc: lipids (amino acids, peptides, and proteins)

<p>Staphylococcus aureus is intrinsically resistant to polymyxins (polymyxin B and colistin), an important class of cationic antimicrobial peptides used in treatment of Gram-negative bacterial infections. To understand the mechanisms underlying intrinsic polymyxin resis... View more
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