A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

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Lin, Juan ; Li, Hanjie ; Yang, Min ; Ren, Junming ; Huang, Zhe ; Han, Felicia ; Huang, Jian ; Ma, Jianhui ; Zhang, Duanwu ; Zhang, Zhirong ; Wu, Jianfeng ; Huang, Deli ; Qiao, Muzhen ; Jin, Guanghui ; Wu, Qiao ; Huang, Yinghui ; Du, Jie ; Han, Jiahuai (2013)
  • Publisher: Elsevier BV
  • Journal: Cell Reports, volume 3, issue 1, pages 200-210 (issn: 2211-1247)
  • Related identifiers: doi: 10.1016/j.celrep.2012.12.012
  • Subject: Biology (General) | QH301-705.5

Necrotic death of macrophages has long been known to be present in atherosclerotic lesions but has not been studied. We examined the role of receptor interacting protein (RIP) 3, a mediator of necrotic cell death, in atherosclerosis and found that RIP3−/−;Ldlr−/− mice w... View more
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