Selective Constraints in Experimentally Defined Primate Regulatory Regions

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Daniel J Gaffney; Ran Blekhman; Jacek Majewski;
  • Publisher: Public Library of Science
  • Journal: PLoS Genetics,volume 4,issue 8 (issn: 1553-7390, eissn: 1553-7404)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pgen.1000157, pmc: PMC2490716
  • Subject: QH426-470 | Evolutionary Biology/Evolutionary and Comparative Genetics | Genetics | Research Article | Evolutionary Biology | Evolutionary Biology/Human Evolution | Genetics and Genomics/Gene Expression | Genetics and Genomics/Population Genetics

Changes in gene regulation may be important in evolution. However, the evolutionary properties of regulatory mutations are currently poorly understood. This is partly the result of an incomplete annotation of functional regulatory DNA in many species. For example, trans... View more
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