CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain.

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Thomas, Luke W.; Stephen, Jenna M.; Esposito, Cinzia; Hoer, Simon; Antrobus, Robin; Ahmed, Afshan; Al-Habib, Hasan; Ashcroft, Margaret;

Background Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. However, mitochondria are required for intracellular... View more
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