publication . Article . 2013

Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase Expression

Park, Hwayong; Song, Kwang Hoon; Jung, Pil Mun; Kim, Ji-Eun; Ro, Hyunju; Kim, Mi Yoon; Ma, Jin Yeul;
Open Access English
  • Published: 01 May 2013 Journal: Evidence-Based Complementary and Alternative Medicine, volume 2,013 (issn: 1741-427X, eissn: 1741-4288, Copyright policy)
  • Publisher: Hindawi Limited
Abstract
To identify the active compound arctigenin in Fructus Arctii (dried seed of medicinal plant Arctium lappa) and to elucidate the inhibitory mechanism in melanogenesis, we analyzed melanin content and tyrosinase activity on B16BL6 murine melanoma and melan-A cell cultures. Water extracts of Fructus Arctii were shown to inhibit tyrosinase activity in vitro and melanin content in α-melanocyte stimulating hormone-stimulated cells to similar levels as the well-known kojic acid and arbutin, respectively. The active compound arctigenin of Fructus Arctii displayed little or no cytotoxicity at all concentrations examined and decreased the relative melanin content and tyro...
Subjects
free text keywords: Other systems of medicine, Research Article, RZ201-999, Article Subject
57 references, page 1 of 4

Cordell, GA, Colvard, MD. Natural products and traditional medicine: turning on a paradigm. Journal of Natural Products . 2012; 75 (3): 514-525 [PubMed]

Kim, H, Choi, HR, Kim, DS, Park, KC. Topical hypopigmenting agents for pigmentary disorders and their mechanisms of action. Annals of Dermatology . 2012; 24 (1): 1-6 [OpenAIRE] [PubMed]

Solano, F, Briganti, S, Picardo, M, Ghanem, G. Hypopigmenting agents: an updated review on biological, chemical and clinical aspects. Pigment Cell Research . 2006; 19 (6): 550-571 [PubMed] []

Nguyen, DTM, Nguyen, DH, Lyun, HL, Lee, HB, Shin, JH, Kim, EK. Inhibition of melanogenesis by dioctyl phthalate isolated from Nigella glandulifera Freyn. Journal of Microbiology and Biotechnology . 2007; 17 (10): 1585-1590 [PubMed] []

Lv, N, Koo, JH, Yoon, HY. Effect of Angelica gigas extract on melanogenesis in B16 melanoma cells. International Journal of Molecular Medicine . 2007; 20 (5): 763-767 [PubMed] []

Windisch, W, Schedle, K, Plitzner, C, Kroismayr, A. Use of phytogenic products as feed additives for swine and poultry. Journal of Animal science . 2008; 86 (14): E140-E148 [PubMed] []

Mukherjee, PK, Ponnusankar, S, Pandit, S, Hazam, PK, Ahmmed, M, Mukherjee, K. Botanicals as medicinal food and their effects on drug metabolizing enzymes. Food and Chemical Toxicology . 2011; 49 (12): 3142-3153 [PubMed]

McGovern, PE, Christofidou-Solomidou, M, Wang, W, Dukes, F, Davidson, T, El-Deiry, WS. Anticancer activity of botanical compounds in ancient fermented beverages. International Journal of Oncology . 2010; 37 (1): 5-14 [PubMed] []

Guimarães, R, Barros, L, Carvalho, AM, Ferreira, ICFR. Studies on chemical constituents and bioactivity of Rosa micrantha: an alternative antioxidants source for food, pharmaceutical, or cosmetic applications. Journal of Agricultural and Food Chemistry . 2010; 58 (10): 6277-6284 [PubMed] []

Shu, YT, Weng, CS, Kuo, WG, Jiang, GJ, Kao, KT. The investigation on the skin whitening efficacy of Chinese herb extracts using the colour physics technology. Journal of Dermatological Science . 2005; 37 (3): 177-179 [PubMed] []

Park, JH, Shin, YG, Shin, UK. Tyrosinase inhibition activity of some herbal drugs. Yakhak Hoeji . 1997; 41 (4): 518-523

Yang, M, Kim, M, Lim, S, Ann, H, Ahn, R. Inhibitory effects of water-acetone extracts of chestnut inner shell, pine needle and hop on the melanin biosynthesis. Yakhak Hoeji . 1999; 43 (4): 494-501

Gillbro, JM, Olsson, MJ. The melanogenesis and mechanisms of skin-lightening agents—existing and new approaches. International Journal of Cosmetic Science . 2011; 33 (3): 210-221 [PubMed] []

Mapunya, MB, Nikolova, RV, Lall, N. Melanogenesis and antityrosinase activity of selected South African plants. Evidence-Based Complementary and Alternative Medicine . 2012; 2012: 6 pages [OpenAIRE] []

Sturm, RA, Teasdale, RD, Box, NF. Human pigmentation genes: identification, structure and consequences of polymorphic variation. Gene . 2001; 277 (1-2): 49-62 [PubMed] []

57 references, page 1 of 4
Abstract
To identify the active compound arctigenin in Fructus Arctii (dried seed of medicinal plant Arctium lappa) and to elucidate the inhibitory mechanism in melanogenesis, we analyzed melanin content and tyrosinase activity on B16BL6 murine melanoma and melan-A cell cultures. Water extracts of Fructus Arctii were shown to inhibit tyrosinase activity in vitro and melanin content in α-melanocyte stimulating hormone-stimulated cells to similar levels as the well-known kojic acid and arbutin, respectively. The active compound arctigenin of Fructus Arctii displayed little or no cytotoxicity at all concentrations examined and decreased the relative melanin content and tyro...
Subjects
free text keywords: Other systems of medicine, Research Article, RZ201-999, Article Subject
57 references, page 1 of 4

Cordell, GA, Colvard, MD. Natural products and traditional medicine: turning on a paradigm. Journal of Natural Products . 2012; 75 (3): 514-525 [PubMed]

Kim, H, Choi, HR, Kim, DS, Park, KC. Topical hypopigmenting agents for pigmentary disorders and their mechanisms of action. Annals of Dermatology . 2012; 24 (1): 1-6 [OpenAIRE] [PubMed]

Solano, F, Briganti, S, Picardo, M, Ghanem, G. Hypopigmenting agents: an updated review on biological, chemical and clinical aspects. Pigment Cell Research . 2006; 19 (6): 550-571 [PubMed] []

Nguyen, DTM, Nguyen, DH, Lyun, HL, Lee, HB, Shin, JH, Kim, EK. Inhibition of melanogenesis by dioctyl phthalate isolated from Nigella glandulifera Freyn. Journal of Microbiology and Biotechnology . 2007; 17 (10): 1585-1590 [PubMed] []

Lv, N, Koo, JH, Yoon, HY. Effect of Angelica gigas extract on melanogenesis in B16 melanoma cells. International Journal of Molecular Medicine . 2007; 20 (5): 763-767 [PubMed] []

Windisch, W, Schedle, K, Plitzner, C, Kroismayr, A. Use of phytogenic products as feed additives for swine and poultry. Journal of Animal science . 2008; 86 (14): E140-E148 [PubMed] []

Mukherjee, PK, Ponnusankar, S, Pandit, S, Hazam, PK, Ahmmed, M, Mukherjee, K. Botanicals as medicinal food and their effects on drug metabolizing enzymes. Food and Chemical Toxicology . 2011; 49 (12): 3142-3153 [PubMed]

McGovern, PE, Christofidou-Solomidou, M, Wang, W, Dukes, F, Davidson, T, El-Deiry, WS. Anticancer activity of botanical compounds in ancient fermented beverages. International Journal of Oncology . 2010; 37 (1): 5-14 [PubMed] []

Guimarães, R, Barros, L, Carvalho, AM, Ferreira, ICFR. Studies on chemical constituents and bioactivity of Rosa micrantha: an alternative antioxidants source for food, pharmaceutical, or cosmetic applications. Journal of Agricultural and Food Chemistry . 2010; 58 (10): 6277-6284 [PubMed] []

Shu, YT, Weng, CS, Kuo, WG, Jiang, GJ, Kao, KT. The investigation on the skin whitening efficacy of Chinese herb extracts using the colour physics technology. Journal of Dermatological Science . 2005; 37 (3): 177-179 [PubMed] []

Park, JH, Shin, YG, Shin, UK. Tyrosinase inhibition activity of some herbal drugs. Yakhak Hoeji . 1997; 41 (4): 518-523

Yang, M, Kim, M, Lim, S, Ann, H, Ahn, R. Inhibitory effects of water-acetone extracts of chestnut inner shell, pine needle and hop on the melanin biosynthesis. Yakhak Hoeji . 1999; 43 (4): 494-501

Gillbro, JM, Olsson, MJ. The melanogenesis and mechanisms of skin-lightening agents—existing and new approaches. International Journal of Cosmetic Science . 2011; 33 (3): 210-221 [PubMed] []

Mapunya, MB, Nikolova, RV, Lall, N. Melanogenesis and antityrosinase activity of selected South African plants. Evidence-Based Complementary and Alternative Medicine . 2012; 2012: 6 pages [OpenAIRE] []

Sturm, RA, Teasdale, RD, Box, NF. Human pigmentation genes: identification, structure and consequences of polymorphic variation. Gene . 2001; 277 (1-2): 49-62 [PubMed] []

57 references, page 1 of 4
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publication . Article . 2013

Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase Expression

Park, Hwayong; Song, Kwang Hoon; Jung, Pil Mun; Kim, Ji-Eun; Ro, Hyunju; Kim, Mi Yoon; Ma, Jin Yeul;