Hypothalamic Gene Transfer of BDNF Inhibits Breast Cancer Progression and Metastasis in Middle Age Obese Mice

Article, Other literature type English OPEN
Liu, Xianglan; McMurphy, Travis; Xiao, Run; Slater, Andrew; Huang, Wei; Cao, Lei;
  • Publisher: Elsevier BV
  • Journal: Molecular Therapy,volume 22,issue 7,pages1,275-1,284 (issn: 1525-0016)
  • Related identifiers: pmc: PMC4089014, doi: 10.1038/mt.2014.45
  • Subject: Molecular Biology | Original Article | Genetics | Drug Discovery | Pharmacology | Molecular Medicine

Activation of the hypothalamus-adipocyte axis is associated with an antiobesity and anticancer phenotype in animal models of melanoma and colon cancer. Brain-derived neurotrophic factor (BDNF) is a key mediator in the hypothalamus leading to preferential sympathoneural ... View more
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