Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha

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Guolin Li; Chad N. Brocker; Tingting Yan; Cen Xie; Kristopher W. Krausz; Rong Xiang; Frank J. Gonzalez;

Background: Peroxisome proliferator-activated receptor alpha (PPARA) is a major regulator of fatty acid oxidation and severe hepatic steatosis occurs during acute fasting in Ppara-null mice. Thus, PPARA is considered an important mediator of the fasting response; howeve... View more
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