Smoking Status and Metabolic Syndrome in the Multi-Ethnic Study of Atherosclerosis. A cross-sectional study

Article English OPEN
Ivan Berlin ; Susan Lin ; Joao A. C. Lima ; Alain Gerald Bertoni (2012)
  • Publisher: E.U.E.P. European Publishing
  • Journal: Tobacco Induced Diseases, volume 10, issue 1, pages 9-9 (issn: 1617-9625, eissn: 1617-9625)
  • Related identifiers: pmc: PMC3489525, doi: 10.1186/1617-9625-10-9
  • Subject: Medicine (miscellaneous) | [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie | Diseases of the respiratory system | body mass index | [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie | [SDV.SPEE] Life Sciences [q-bio]/Public Health and Epidemiology | Research | Neoplasms. Tumors. Oncology. Including cancer and carcinogens | metabolic syndrome | smoking | ethnic groups | Health(social science) | RC254-282 | RC705-779 | Public Health, Environmental and Occupational Health

Background Current smoking is associated with type 2 diabetes mellitus and impaired glucose tolerance but its association with the metabolic syndrome (metS), particularly with sufficiently sampled African American representation, has not been clearly established. Objective To assess whether a) metS is associated with smoking; b) any increased risk of metS among smokers is independent of body mass index (BMI) compared with non-smokers; c) smoking status is differentially associated with the metS and its components across different ethnic groups. Methods Cross sectional analysis of the Multi-Ethnic Study of Atherosclerosis (MESA) a community populationbased sample free of cardiovascular disease. Results Current smokers (N = 769) had higher risk of metS (odds ratio [OR, 95% confidence interval]: 1.4, 1.1-1.7) versus never (reference, N = 2981) and former smokers (1.0, 0.8-1.1, N = 2163) and for metS components: high waist circumference (WC) (OR:1.9, 1.2-2.1), low high density lipoprotein cholesterol (HDL-C) (1.5, 1.3-1.8), elevated plasma triglycerides (TG) (OR:1.4, 1.2-1.7) as well as high C-reactive protein (CRP, an inflammatory marker) concentration (OR: 1.6,1.3-2.0) compared to never and former smokers after adjustment for BMI. A smoking status by ethnicity interaction occurred such that African American current and former smokers had greater likelihood of low HDL-C than White counterparts. Conclusions This study found that smoking is associated with the metS and despite the lower BMI of current smokers the prevalence of low HDL-C, elevated TG and CRP is higher among them than among non-smokers. African Americans generally have higher HDL-C than Whites but smoking wipes out this advantage. Multi-Ethnic Study of Atherosclerosis (MESA) Identifier: NCT00005487
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