Intrathecal anti-CD20 efficiently depletes meningeal B cells in CNS autoimmunity

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Lehmann-Horn, Klaus; Kinzel, Silke; Feldmann, Linda; Radelfahr, Florentine; Hemmer, Bernhard; Traffehn, Sarah; Bernard, Claude C. A.; Stadelmann, Christine; Brück, Wolfgang; Weber, Martin S.;

Clinical trials revealed that systemic administration of B-cell-depleting anti-CD20 antibodies can hold lesion formation in the early relapsing-remitting phase of multiple sclerosis (MS). Throughout the secondary-progressive (SP) course of MS, pathogenic B cells may, ho... View more
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