miR-217 Regulates Ethanol-Induced Hepatic Inflammation by Disrupting Sirtuin 1–Lipin-1 Signaling

Article, Other literature type English OPEN
Yin, Huquan; Liang, Xiaomei; Jogasuria, Alvin; Davidson, Nicholas O.; You, Min; (2015)
  • Publisher: Elsevier BV
  • Journal: The American Journal of Pathology,volume 185,issue 5,pages1,286-1,296 (issn: 0002-9440)
  • Related identifiers: pmc: PMC4419208, doi: 10.1016/j.ajpath.2015.01.030
  • Subject: Regular Article | Pathology and Forensic Medicine

Ethanol-mediated injury, combined with gut-derived lipopolysaccharide (LPS), provokes generation of proinflammatory cytokines in Kupffer cells, causing hepatic inflammation. Among the mediators of these effects, miR-217 aggravates ethanol-induced steatosis in hepatocyte... View more
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