HIF-1α Is Essential for Effective PMN Bacterial Killing, Antimicrobial Peptide Production and Apoptosis in Pseudomonas aeruginosa Keratitis

Article English OPEN
Berger, Elizabeth A.; McClellan, Sharon A.; Vistisen, Kerry S.; Hazlett, Linda D.; (2013)
  • Publisher: Public Library of Science
  • Journal: PLoS Pathogens,volume 9,issue 7 (issn: 1553-7366, eissn: 1553-7374)
  • Related identifiers: doi: 10.1371/journal.ppat.1003457, pmc: PMC3715414
  • Subject: RC581-607 | Research Article | Biology | Medicine | Immunologic diseases. Allergy | Biology (General) | QH301-705.5

Hypoxia-inducible factor (HIF)-1α, is a transcription factor that controls energy metabolism and angiogenesis under hypoxic conditions, and a potent regulator of innate immunity. The studies described herein examined the role of HIF-1α in disease resolution in BALB/c (r... View more
Share - Bookmark