Long-lived tissue resident HIV-1 specific memory CD8+ T cells are generated by skin immunization with live virus vectored microneedle arrays

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Zaric, Marija; Becker, Pablo Daniel; Hervouet, Catherine; Kalcheva, Petya; Ibarzo Yus, Barbara; Cocita, Clement; O'Neill, Lauren Alexandra; Kwon, Sung-Yun; Klavinskis, Linda Sylvia;
  • Publisher: Elsevier Science Publishers
  • Journal: Journal of Controlled Release,volume 268,pages166-175 (issn: 0168-3659, eissn: 1873-4995)
  • Related identifiers: doi: 10.1016/j.jconrel.2017.10.026, pmc: PMC5735037
  • Subject: Tissue resident CD8 | Memory | Mucosal tissue | HIV | Microneedles | Viral vector | Article

The generation of tissue resident memory (TRM) cells at the body surfaces to provide a front line defence against invading pathogens represents an important goal in vaccine development for a wide variety of pathogens. It has been widely assumed that local vaccine delive... View more
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