Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis.

Article English OPEN
Maria C Lebre; Clarissa E Vergunst; Ivy Y K Choi; Saïda Aarrass; Ana S F Oliveira; Tim Wyant; Richard Horuk; Kris A Reedquist; Paul P Tak;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 6,issue 7 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3128605, doi: 10.1371/journal.pone.0021772
  • Subject: Immune System Proteins | Autoimmune Diseases | Monocytes | Research Article | Biology | Rheumatology | Immune Cells | Medicine | Immunity | Rheumatoid Arthritis | Q | R | Autoimmunity | Inflammation | Proteins | Clinical Immunology | Biochemistry | Science | Immunology
    mesheuropmc: hemic and immune systems

BACKGROUND: The aim of this study was to provide more insight into the question as to why blockade of CCR1, CCR2, and CCR5 may have failed in clinical trials in rheumatoid arthritis (RA) patients, using an in vitro monocyte migration system model. METHODOLOGY/PRINCIPAL ... View more
  • References (36)
    36 references, page 1 of 4

    1. Katschke KJ, Jr., Rottman JB, Ruth JH, Qin S, Wu L, et al. (2001) Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis. Arthritis Rheum 44: 1022-1032.

    2. Haringman JJ, Ludikhuize J, Tak PP (2004) Chemokines in joint disease: the key to inflammation? Ann Rheum Dis 63: 1186-1194.

    3. Tak PP, Smeets TJ, Daha MR, Kluin PM, Meijers KA, et al. (1997) Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum 40: 217-225.

    4. Wijbrandts CA, Vergunst CE, Haringman JJ, Gerlag DM, Smeets TJ, et al. (2007) Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker. Arthritis Rheum 56: 3869-3871.

    5. Kinne RW, Stuhlmuller B, Burmester GR (2007) Cells of the synovium in rheumatoid arthritis. Macrophages. Arthritis Res Ther 9: 224.

    6. Hamilton JA, Tak PP (2009) The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases. Arthritis Rheum 60: 1210-1221.

    7. Sallusto F, Mackay CR, Lanzavecchia A (2000) The role of chemokine receptors in primary, effector, and memory immune responses. Annual Review of Immunology 18: 593-620.

    8. Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, et al. (2008) Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol 181: 8053-8067.

    9. Patel DD, Zachariah JP, Whichard LP (2001) CXCR3 and CCR5 ligands in rheumatoid arthritis synovium. Clin Immunol 98: 39-45.

    10. Haringman JJ, Smeets TJ, Reinders-Blankert P, Tak PP (2006) Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann Rheum Dis 65: 294-300.

  • Related Research Results (2)
  • Metrics
Share - Bookmark