publication . Article . 2018

Entomopathogenic fungal infection leads to temporospatial modulation of the mosquito immune system.

Ramirez, José L.; Dunlap, Christopher A.; Muturi, Ephantus J.; Barletta, Ana B. F.; Rooney, Alejandro P.;
Open Access English
  • Published: 01 Apr 2018 Journal: PLoS Neglected Tropical Diseases, volume 12, issue 4 (issn: 1935-2727, eissn: 1935-2735, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Abstract
Alternative methods of mosquito control are needed to tackle the rising burden of mosquito-borne diseases while minimizing the use of synthetic insecticides, which are threatened by the rapid increase in insecticide resistance in mosquito populations. Fungal biopesticides show great promise as potential alternatives because of their ecofriendly nature and ability to infect mosquitoes on contact. Here we describe the temporospatial interactions between the mosquito Aedes aegypti and several entomopathogenic fungi. Fungal infection assays followed by the molecular assessment of infection-responsive genes revealed an intricate interaction between the mosquito immun...
Subjects
mesheuropmc: fungiparasitic diseases
free text keywords: Microbial Pathogens, Lipids, Research Article, Eukaryota, Infectious Diseases, Pathology and Laboratory Medicine, Genetics, Pathogens, Fats, Immune Response, Species Interactions, Animals, Fungal Diseases, Fungal Pathogens, Immunology, Disease Vectors, Mosquitoes, Biology and Life Sciences, Insect Vectors, Arthropoda, Microbiology, Insects, Fungal Genetics, Medical Microbiology, RC955-962, RA1-1270, Public aspects of medicine, Biochemistry, Organisms, Medicine and Health Sciences, Arctic medicine. Tropical medicine, Invertebrates, Mycology, Gene Expression
68 references, page 1 of 5

1 Farenhorst M, Farina D, Scholte EJ, Takken W, Hunt RH, Coetzee M, et al African water storage pots for the delivery of the entomopathogenic fungus Metarhizium anisopliae to the malaria vectors Anopheles gambiae s.s. and Anopheles funestus. Am J Trop Med Hyg. 2008;78(6):910–6. .18541768 [OpenAIRE] [PubMed]

2 Scholte EJ, Knols BG, Samson RA, Takken W. Entomopathogenic fungi for mosquito control: a review. J Insect Sci. 2004;4(19):19 doi: 10.1673/031.004.1901 ; PubMed Central PMCID: PMCPMC528879.15861235 [OpenAIRE] [PubMed]

3 Alkhaibari AM, Carolino AT, Bull JC, Samuels RI, Butt TM. Differential Pathogenicity of Metarhizium Blastospores and Conidia Against Larvae of Three Mosquito Species. Journal of Medical Entomology. 2017;54(3):696–704. doi: 10.1093/jme/tjw223 28399202 [PubMed]

4 Alkhaibari AM, Carolino AT, Yavasoglu SI, Maffeis T, Mattoso TC, Bull JC, et al Metarhizium brunneum Blastospore Pathogenesis in Aedes aegypti Larvae: Attack on Several Fronts Accelerates Mortality. PLOS Pathogens. 2016;12(7):e1005715 doi: 10.1371/journal.ppat.1005715 27389584 [OpenAIRE] [PubMed]

5 Becker N, Lüthy P. Chapter 26—Mosquito Control With Entomopathogenic Bacteria in Europe A2—Lacey, Lawrence A Microbial Control of Insect and Mite Pests: Academic Press; 2016 p. 379–92.

6 Pelizza SA, Scorsetti AC, Tranchida MC. The sublethal effects of the entomopathic fungus Leptolegnia chapmanii on some biological parameters of the dengue vector Aedes aegypti. J Insect Sci. 2013;13(22):22 doi: 10.1673/031.013.2201 ; PubMed Central PMCID: PMCPMC3735114.23901823 [OpenAIRE] [PubMed]

7 Blanford S, Chan BH, Jenkins N, Sim D, Turner RJ, Read AF, et al Fungal pathogen reduces potential for malaria transmission. Science. 2005;308(5728):1638–41. doi: 10.1126/science.1108423 .15947189 [PubMed]

8 Blanford S, Shi W, Christian R, Marden JH, Koekemoer LL, Brooke BD, et al Lethal and pre-lethal effects of a fungal biopesticide contribute to substantial and rapid control of malaria vectors. PLoS One. 2011;6(8):e23591 doi: 10.1371/journal.pone.0023591 ; PubMed Central PMCID: PMCPMC3163643.21897846 [OpenAIRE] [PubMed]

9 Butt TM, Coates CJ, Dubovskiy IM, Ratcliffe NA. Chapter Nine—Entomopathogenic Fungi: New Insights into Host–Pathogen Interactions In: Brian L, Raymond JSL, editors. Advances in Genetics. Volume 94: Academic Press; 2016 p. 307–64.27131329 [PubMed]

10 Lovett B, St. Leger RJ. The Insect Pathogens. Microbiology Spectrum. 2017;5(2). doi: 10.1128/microbiolspec.FUNK-0001-2016 28256192 [PubMed]

11 Wang YH, Hu Y, Xing LS, Jiang H, Hu SN, Raikhel AS, et al A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes. PLoS Pathog. 2015;11(6):e1004931 doi: 10.1371/journal.ppat.1004931 ; PubMed Central PMCID: PMCPMC4461313.26057557 [OpenAIRE] [PubMed]

12 Gillespie JP, and, Kanost MR, Trenczek T. Biological Mediators of Insect Immunity. Annual Review of Entomology. 1997;42(1):611–43. doi: 10.1146/annurev.ento.42.1.611 .9017902 [PubMed]

13 Silverman N, Zhou R, Erlich R, Hunter M, Bernstein E, Schneider D, et al Immune activation of NF-kappaB and JNK requires Drosophila TAK1. J Biol Chem. 2003;278(49):48928–34. doi: 10.1074/jbc.M304802200 14519762 [PubMed]

14 Tanji T, Hu X, Weber ANR, Ip YT. Toll and IMD Pathways Synergistically Activate an Innate Immune Response in Drosophila melanogaster. Molecular and Cellular Biology. 2007;27(12):4578–88. doi: 10.1128/MCB.01814-06 17438142 [OpenAIRE] [PubMed]

15 Sim S, Jupatanakul N, Dimopoulos G. Mosquito Immunity against Arboviruses. Viruses. 2014;6(11):4479–504. doi: 10.3390/v6114479. PMC4246235. 25415198 [OpenAIRE] [PubMed]

68 references, page 1 of 5
Abstract
Alternative methods of mosquito control are needed to tackle the rising burden of mosquito-borne diseases while minimizing the use of synthetic insecticides, which are threatened by the rapid increase in insecticide resistance in mosquito populations. Fungal biopesticides show great promise as potential alternatives because of their ecofriendly nature and ability to infect mosquitoes on contact. Here we describe the temporospatial interactions between the mosquito Aedes aegypti and several entomopathogenic fungi. Fungal infection assays followed by the molecular assessment of infection-responsive genes revealed an intricate interaction between the mosquito immun...
Subjects
mesheuropmc: fungiparasitic diseases
free text keywords: Microbial Pathogens, Lipids, Research Article, Eukaryota, Infectious Diseases, Pathology and Laboratory Medicine, Genetics, Pathogens, Fats, Immune Response, Species Interactions, Animals, Fungal Diseases, Fungal Pathogens, Immunology, Disease Vectors, Mosquitoes, Biology and Life Sciences, Insect Vectors, Arthropoda, Microbiology, Insects, Fungal Genetics, Medical Microbiology, RC955-962, RA1-1270, Public aspects of medicine, Biochemistry, Organisms, Medicine and Health Sciences, Arctic medicine. Tropical medicine, Invertebrates, Mycology, Gene Expression
68 references, page 1 of 5

1 Farenhorst M, Farina D, Scholte EJ, Takken W, Hunt RH, Coetzee M, et al African water storage pots for the delivery of the entomopathogenic fungus Metarhizium anisopliae to the malaria vectors Anopheles gambiae s.s. and Anopheles funestus. Am J Trop Med Hyg. 2008;78(6):910–6. .18541768 [OpenAIRE] [PubMed]

2 Scholte EJ, Knols BG, Samson RA, Takken W. Entomopathogenic fungi for mosquito control: a review. J Insect Sci. 2004;4(19):19 doi: 10.1673/031.004.1901 ; PubMed Central PMCID: PMCPMC528879.15861235 [OpenAIRE] [PubMed]

3 Alkhaibari AM, Carolino AT, Bull JC, Samuels RI, Butt TM. Differential Pathogenicity of Metarhizium Blastospores and Conidia Against Larvae of Three Mosquito Species. Journal of Medical Entomology. 2017;54(3):696–704. doi: 10.1093/jme/tjw223 28399202 [PubMed]

4 Alkhaibari AM, Carolino AT, Yavasoglu SI, Maffeis T, Mattoso TC, Bull JC, et al Metarhizium brunneum Blastospore Pathogenesis in Aedes aegypti Larvae: Attack on Several Fronts Accelerates Mortality. PLOS Pathogens. 2016;12(7):e1005715 doi: 10.1371/journal.ppat.1005715 27389584 [OpenAIRE] [PubMed]

5 Becker N, Lüthy P. Chapter 26—Mosquito Control With Entomopathogenic Bacteria in Europe A2—Lacey, Lawrence A Microbial Control of Insect and Mite Pests: Academic Press; 2016 p. 379–92.

6 Pelizza SA, Scorsetti AC, Tranchida MC. The sublethal effects of the entomopathic fungus Leptolegnia chapmanii on some biological parameters of the dengue vector Aedes aegypti. J Insect Sci. 2013;13(22):22 doi: 10.1673/031.013.2201 ; PubMed Central PMCID: PMCPMC3735114.23901823 [OpenAIRE] [PubMed]

7 Blanford S, Chan BH, Jenkins N, Sim D, Turner RJ, Read AF, et al Fungal pathogen reduces potential for malaria transmission. Science. 2005;308(5728):1638–41. doi: 10.1126/science.1108423 .15947189 [PubMed]

8 Blanford S, Shi W, Christian R, Marden JH, Koekemoer LL, Brooke BD, et al Lethal and pre-lethal effects of a fungal biopesticide contribute to substantial and rapid control of malaria vectors. PLoS One. 2011;6(8):e23591 doi: 10.1371/journal.pone.0023591 ; PubMed Central PMCID: PMCPMC3163643.21897846 [OpenAIRE] [PubMed]

9 Butt TM, Coates CJ, Dubovskiy IM, Ratcliffe NA. Chapter Nine—Entomopathogenic Fungi: New Insights into Host–Pathogen Interactions In: Brian L, Raymond JSL, editors. Advances in Genetics. Volume 94: Academic Press; 2016 p. 307–64.27131329 [PubMed]

10 Lovett B, St. Leger RJ. The Insect Pathogens. Microbiology Spectrum. 2017;5(2). doi: 10.1128/microbiolspec.FUNK-0001-2016 28256192 [PubMed]

11 Wang YH, Hu Y, Xing LS, Jiang H, Hu SN, Raikhel AS, et al A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes. PLoS Pathog. 2015;11(6):e1004931 doi: 10.1371/journal.ppat.1004931 ; PubMed Central PMCID: PMCPMC4461313.26057557 [OpenAIRE] [PubMed]

12 Gillespie JP, and, Kanost MR, Trenczek T. Biological Mediators of Insect Immunity. Annual Review of Entomology. 1997;42(1):611–43. doi: 10.1146/annurev.ento.42.1.611 .9017902 [PubMed]

13 Silverman N, Zhou R, Erlich R, Hunter M, Bernstein E, Schneider D, et al Immune activation of NF-kappaB and JNK requires Drosophila TAK1. J Biol Chem. 2003;278(49):48928–34. doi: 10.1074/jbc.M304802200 14519762 [PubMed]

14 Tanji T, Hu X, Weber ANR, Ip YT. Toll and IMD Pathways Synergistically Activate an Innate Immune Response in Drosophila melanogaster. Molecular and Cellular Biology. 2007;27(12):4578–88. doi: 10.1128/MCB.01814-06 17438142 [OpenAIRE] [PubMed]

15 Sim S, Jupatanakul N, Dimopoulos G. Mosquito Immunity against Arboviruses. Viruses. 2014;6(11):4479–504. doi: 10.3390/v6114479. PMC4246235. 25415198 [OpenAIRE] [PubMed]

68 references, page 1 of 5
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publication . Article . 2018

Entomopathogenic fungal infection leads to temporospatial modulation of the mosquito immune system.

Ramirez, José L.; Dunlap, Christopher A.; Muturi, Ephantus J.; Barletta, Ana B. F.; Rooney, Alejandro P.;