Oxacillin sensitization of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius by antisense peptide nucleic acids in vitro

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Goh, Shan ; Loeffler, Anette ; Lloyd, David H. ; Nair, Sean P. ; Good, Liam (2015)
  • Publisher: BioMed Central
  • Journal: BMC Microbiology, volume 15 (issn: 1471-2180, eissn: 1471-2180)
  • Related identifiers: pmc: PMC4642645, doi: 10.1186/s12866-015-0599-x
  • Subject: MRSA | Research Article | mecA | ftsZ | Methicillin-resistant Staphylococcus pseudintermedius | Antisense, mecA, ftsZ, MRSA, Methicillin-resistant Staphylococcus pseudintermedius | Microbiology (medical) | Antisense
    mesheuropmc: biochemical phenomena, metabolism, and nutrition

Background Antibiotic resistance genes can be targeted by antisense agents, which can reduce their expression and thus restore cellular susceptibility to existing antibiotics. Antisense inhibitors can be gene and pathogen specific, or designed to inhibit a group of bact... View more
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