Electronegative Low-Density Lipoprotein Increases C-Reactive Protein Expression in Vascular Endothelial Cells through the LOX-1 Receptor

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Chih-Sheng Chu; Yu-Chen Wang; Long-Sheng Lu; Brian Walton; H Ramazan Yilmaz; Roger Y Huang; Tatsuya Sawamura; Richard A F Dixon; Wen-Ter Lai; Chu-Huang Chen; Jonathan Lu;
  • Journal: PLOS ONE, volume 8, issue 8,pagee70533 (issn: 1932-6203, eissn: 1932-6203)
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  • Identifiers: doi: 10.1371/journal.pone.0070533, pmc: PMC3738565
  • Subject: Chemistry | Atherosclerosis | Research Article | Biology | Molecular Cell Biology | Diagnostic Medicine | Medicine | Cardiovascular | Lipoprotein Receptors | Q | R | Proteins | Science | Biochemistry | Chromatography | Lipoproteins
    mesheuropmc: lipids (amino acids, peptides, and proteins)

Objectives Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most electronegative subfractio... View more
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