The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)

Article English OPEN
Yi, Colin J ; Wu, Colin O ; Tee, Michael ; Liu, Chia-Ying ; Volpe, Gustavo J ; Prince, Martin R ; Hundley, Gregory W ; Gomes, Antoinette S ; van der Geest, Rob J ; Heckbert, Susan ; Lima, João A ; Bluemke, David A (2015)
  • Publisher: Springer Nature
  • Journal: Journal of Cardiovascular Magnetic Resonance, volume 17, issue 1, page 15 (issn: 1532-429X, eissn: 1532-429X)
  • Related identifiers: doi: 10.1186/s12968-015-0121-5, pmc: PMC4326517
  • Subject: Risk factors | Medicine(all) | Myocardium | Cardiovascular magnetic resonance | Research
    mesheuropmc: cardiovascular diseases

Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have T1 mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. T1 times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native T1, 12 and 25 minute post-gadolinium T1, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium T1 time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native T1 (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. T1 times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native T1 time. Clinical trial registration, NCT00005487.
  • References (33)
    33 references, page 1 of 4

    1. Kannel WB, Kagan A, Stokes J, Dawber TR, Revotskie N. Factors of Risk in Development of Coronary Heart Disease - 6-Year Follow-up Experience. Ann Intern Med. 1961;55:33-50.

    2. Bitton A, Gaziano T. The Framingham Heart Study's Impact on Global Risk Assessment. Prog Cardiovasc Dis. 2010;53:68-78.

    3. Kannel WB, McGee D, Gordon T. A general cardiovascular risk profile: the Framingham Study. Am J Cardiol. 1976;38:46-51.

    4. Anderson KM, Wilson PW, Odell PM, Kannel WB. An updated coronary risk profile. A statement for health professionals. Circulation. 1991;83:356-62.

    5. Goff Jr DC, Lloyd-Jones DM, Bennett G, Coady S, D'Agostino Sr RB, Gibbons R, et al. ACC/AHA Guideline on the Assessment of Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;63:3026.

    6. Polonsky TS, McClelland RL, Jorgensen NW, Bild DE, Burke GL, Guerci AD, et al. Coronary Artery Calcium Score and Risk Classification for Coronary Heart Disease Prediction. J Am Med Assoc. 2010;303:1610-6.

    7. Pitt B, Zannad F. The detection of myocardial fibrosis: an opportunity to reduce cardiovascular risk in patients with diabetes mellitus? Circ Cardiovasc Imaging. 2012;5:9-11.

    8. Donekal S, Lima JAC. Diffuse Interstitial Myocardial Fibrosis by T1 Myocardial Mapping: Review. Transl Med. 2013;3:111.

    9. Olivetti G, Giordano G, Corradi D, Melissari M, Lagrasta C, Gambert SR, et al. Gender Differences and Aging - Effects on the Human Heart. J Am Coll Cardiol. 1995;26:1068-79.

    10. Kania G, Blyszczuk P, Eriksson U. Mechanisms of Cardiac Fibrosis in Inflammatory Heart Disease. Trends Cardiovas Med. 2009;19:247-52.

  • Related Research Results (1)
  • Metrics
    No metrics available