A Novel System for Identification of Inhibitors of Rift Valley Fever Virus Replication

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Piper, Mary E. ; Gerrard, Sonja R. (2010)
  • Publisher: Molecular Diversity Preservation International (MDPI)
  • Journal: Viruses, volume 2, issue 3, pages 731-747 (issn: 1999-4915, eissn: 1999-4915)
  • Related identifiers: doi: 10.3390/v2030731, pmc: PMC3185646
  • Subject: RNA virus | antivirals | minigenome | Rift Valley fever | <em>Bunyaviridae</em> | virus-like particle | Bunyaviridae | Microbiology | Phlebovirus | QR1-502 | Article
    mesheuropmc: viruses

Rift Valley fever virus (RVFV) is a human and livestock pathogen endemic to sub-Saharan Africa. We have developed a T7-dependent system for the efficient production of RVFV-like particles (RVF-VLPs) based on the virulent ZH-501 strain of RVFV. The RVF-VLPs are capable o... View more
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