CISH and Susceptibility to Infectious Diseases

Other literature type, Article English OPEN
Khor, CC; Vannberg, FO; Chapman, SJ; Guo, H; Wong, SH; Walley, AJ; Vukcevic, D; Rautanen, A; Mills, TC; Chang, K-C; Kam, K-M; Crampin, AC; Ngwira, B; Leung, C-C; Tam, C-M; Chan, C-Y; Sung, JJY; Yew, W-W; Toh, K-Y; Tay, SKH; Kwiatkowski, D; Lienhardt, C; Hien, T-T; Day, NP; Peshu, N; Marsh, K; Maitland, K; Scott, JA; Williams, TN; Berkley, JA; ... view all 35 authors
(2010)
  • Publisher: MASSACHUSETTS MEDICAL SOC
  • Related identifiers: doi: 10.1056/NEJMoa0905606, pmc: PMC3646238
  • Subject: INTERLEUKIN-2 | Life Sciences & Biomedicine | T-CELLS | TUBERCULOSIS | STAT5 | MALARIA | Article | General & Internal Medicine | SIGNALING PATHWAYS | RECEPTOR | Science & Technology | MEDICINE, GENERAL & INTERNAL | CHILDREN | HUMAN-IMMUNODEFICIENCY-VIRUS | PROTEIN

BACKGROUND The interleukin-2-mediated immune response is critical for host defense against infectious pathogens. Cytokine-inducible SRC homology 2 (SH2) domain protein (CISH), a suppressor of cytokine signaling, controls interleukin-2 signaling. METHODS Using a case-con... View more
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