Protein Domain Analysis of C. botulinum Type A Neurotoxin and Its Relationship with Other Botulinum Serotypes

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Sharma, Shashi K.; Basavanna, Uma; Shukla, Hem D.;

Botulinum neurotoxins (BoNTs) are highly potent poisons produced by seven serotypes of Clostridium botulinum. The mechanism of neurotoxin action is a multistep process which leads to the cleavage of one of three different SNARE proteins essential for synaptic vesicle fu... View more
  • References (26)
    26 references, page 1 of 3

    Li, L.; Singh, B.R. Structure-function relationship of clostridial neurotoxins. J. Toxicol. Toxin Rev. 1999, 18, 95-112.

    Trends Biochem. Sci. 1993, 18, 324−327.

    Schiavo, G.; Malizio, C.; Trimble, W.S.; Polverino de Laureto, P.; Milan, G.; Sugiyama, H.; Johnson, E.A.; Montecucco, C. Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond. J. Biol. Chem. 1994, 269, 20213-20216.

    Burkhard, P.; Kemmerer, R.A.; Steinmetz, M.O.; Bourenkov, G.P.; Aebi, U. The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges. Structure 2000, 8, 223-230.

    Trends. Cell. Biol. 2001, 11, 82-88.

    Swaminathan, S.; Eswaramoorthy, S. Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B. Nat. Struct. Biol. 2000, 7, 693-699.

    Hanson, M.A.; Stevens, R.C. Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 Å resolution. Nat. Struct. Biol. 2000, 7, 687-692.

    9. Lacy, D.B.; Tepp, W.; Cohen, A.C.; DasGupta, B.R.; Stevens, R.C. Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nat. Struct. Biol. 1998, 5, 898-902.

    10. Umland, T.C.; Wingert, L.M.; Swaminathan, S.; Furey, W.F.; Schmidt, J.J.; Sax, M. Structure of the receptor binding fragment HC of tetanus neurotoxin. Nat. Struct. Biol. 1997, 4, 788-792.

    11. Lacy, D.B.; Stevens, R.C. Sequence homology and structural analysis of the clostridial neurotoxins. J. Mol. Biol. 1999, 291, 1091-1104.

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