Regulation of TGFβ in the immune system: An emerging role for integrins and dendritic cells

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Worthington, John J.; Fenton, Thomas M.; Czajkowska, Beata I.; Klementowicz, Joanna E.; Travis, Mark A.;
  • Publisher: Elsevier
  • Journal: Immunobiology,volume 217,issue 12,pages1,259-1,265 (issn: 0171-2985, eissn: 1878-3279)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.imbio.2012.06.009, pmc: PMC3690473
  • Subject: GDF, growth and differentiation factor | T-cell | TGFβR, TGFβ receptor | LAP, latency-associated peptide | iTreg, induced regulatory T-cell | TGFβ | BMP, bone morphogenetic protein | Article | Adaptive immunity | AHR, airway hyper-responsiveness | Hematology | LC, Langerhans cells | nTreg, natural regulatory T-cell | EAE, experimental autoimmune encephalitis | Immunology and Allergy | TGFβ, transforming growth factor β | DC, dendritic cell | Integrin | Immunology | Treg, regulatory T-cell | Dendritic cell

Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell–cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth fac... View more
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