Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation.

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Samelko, Lauryn; Landgraeber, Stefan; McAllister, Kyron; Jacobs, Joshua; Hallab, Nadim James;
(2016)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 11,issue 7 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0160141, pmc: PMC4965114
  • Subject: Immune System Proteins | Research Article | Diagnostic Medicine | Toll-like Receptors | Signs and Symptoms | Pathology and Laboratory Medicine | Cobalt | Chemical Elements | Macrophages | Physical Sciences | White Blood Cells | Immune Response | Inflammation | Proteins | Immunology | Chemistry | Cellular Types | Monocytes | Alloys | Biology and Life Sciences | Immune Receptor Signaling | Materials Science | Inflammasomes | Signal Transduction | Blood Cells | Metallurgy | Immune Cells | Animal Cells | Medicine | Membrane Receptor Signaling | Q | R | Cell Biology | Biochemistry | Cell Signaling | Science | Medicine and Health Sciences | Immune Receptors | Cobalt Alloys

Cobalt alloy debris has been implicated as causative in the early failure of some designs of current total joint implants. The ability of implant debris to cause excessive inflammation via danger signaling (NLRP3 inflammasome) vs. pathogen associated pattern recognition... View more
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