Subject: Immune System Proteins | Research Article | Diagnostic Medicine | Toll-like Receptors | Signs and Symptoms | Pathology and Laboratory Medicine | Cobalt | Chemical Elements | Macrophages | Physical Sciences | White Blood Cells | Immune Response | Inflammation | Proteins | Immunology | Chemistry | Cellular Types | Monocytes | Alloys | Biology and Life Sciences | Immune Receptor Signaling | Materials Science | Inflammasomes | Signal Transduction | Blood Cells | Metallurgy | Immune Cells | Animal Cells | Medicine | Membrane Receptor Signaling | Q | R | Cell Biology | Biochemistry | Cell Signaling | Science | Medicine and Health Sciences | Immune Receptors | Cobalt Alloys
Cobalt alloy debris has been implicated as causative in the early failure of some designs of current total joint implants. The ability of implant debris to cause excessive inflammation via danger signaling (NLRP3 inflammasome) vs. pathogen associated pattern recognition... View more
2 Madl AK, Liong M, Kovochich M, Finley BL, Paustenbach DJ, Oberdorster G. Toxicology of wear particles of cobalt-chromium alloy metal-on-metal hip implants Part I: Physicochemical properties in patient and simulator studies. Nanomedicine 2015 3 3.
5 Hallab NJ, McAllister K, Brady M, Jarman-Smith M. Macrophage reactivity to different polymers demonstrates particle size- and material-specific reactivity: PEEK-OPTIMA((R)) particles versus UHMWPE particles in the submicron, micron, and 10 micron size ranges. J Biomed Mater Res B Appl Biomater 2011 11 21.