CD8+ T Cells Mediate Female-Dominant IL-4 Production and Airway Inflammation in Allergic Asthma.

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Chihiro Ito; Kaori Okuyama-Dobashi; Tomomitsu Miyasaka; Chiaki Masuda; Miki Sato; Tasuku Kawano; Yuichi Ohkawara; Toshiaki Kikuchi; Motoaki Takayanagi; Isao Ohno;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 10,issue 10 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC4619475, doi: 10.1371/journal.pone.0140808
  • Subject: Q | R | Research Article | Science | Medicine

The prevalence and severity of bronchial asthma are higher in females than in males after puberty. Although antigen-specific CD8+ T cells play an important role in the development of asthma through their suppressive effect on cytokine production, the contribution of CD8... View more
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