Glucocorticosteroids associated with a decreased risk of psychosis.

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Laan, Wijnand; Smeets, Hugo; de Wit, Niek J.; Kahn, Rene S.; Grobbee, Diederick E.; Burger, Huibert;
  • Subject: inflammation | CELECOXIB | THERAPY | glucocorticosteroids | SCHIZOPHRENIA | UMCG Approved | psychosis

The hypothesis that chronic inflammation may play a role in psychosis receives increasing attention. In this study, we aim to investigate whether the use of steroidal anti-inflammatory drugs is associated with a decreased risk of psychosis. A longitudinal nested case-co... View more
  • References (12)
    12 references, page 1 of 2

    1. Freedman R. Schizophrenia. N Engl J Med. 2003;349(18):1738Y1749.

    2. Wiersma D, Nienhuis FJ, Slooff CJ, et al. Natural course of schizophrenic disorders: a 15-year followup of a Dutch incidence cohort. Schizophr Bull. 1998;24(1):75Y85.

    3. Laan W, Selten JP, Grobbee DE, et al. Non-steroidal anti-inflammatory drugs and the risk of psychosis. Eur Neuropsychopharmacol. 2007; 17(4):309Y311.

    4. Akhondzadeh S, Tabatabaee M, Amini H, et al. Celecoxib as adjunctive

    5. Mu¨ller N, Riedel M, Scheppach C, et al. Beneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia. Am J Psychiatry. 2002;159(6):1029Y1034.

    6. Potvin S, Stip E, Sepehry AA, et al. Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry. 2008;63(8):801Y808.

    7. Yilmaz N, Herken H, Cicek HK, et al. Increased levels of nitric oxide, cortisol and adrenomedullin in patients with chronic schizophrenia. Med Princ Pract. 2007;16(2):137Y141.

    8. Riad M, Mogos M, Thangathurai D, et al. Steroids. Curr Opin Crit Care. 2002;8(4):281Y284.

    9. van Haren NE, Hulshoff Pol HE, Schnack HG, et al. Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthood. Biol Psychiatry. 2008;63(1):106Y113.

    10. Daley-Yates PT, Price AC, Sisson JR, et al. Beclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in man. Br J Clin Pharmacol. 2001;51(5):400Y409.

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