publication . Article . Other literature type . 2012

Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl

Zhu, Wei; Pao, Gerald M.; Satoh, Akira; Cummings, Gillian; Monaghan, James R.; Harkins, Timothy T.; Bryant, Susan V.; Randal Voss, S.; Gardiner, David M.; Hunter, Tony;
Open Access English
  • Published: 01 Oct 2012 Journal: volume 370, issue 1, pages 42-51issn: 0012-1606, Copyright policy
  • Publisher: eScholarship, University of California
Abstract
The capacity for tissue and organ regeneration in humans is dwarfed by comparison to that of salamanders. Emerging evidence suggests that mechanisms learned from the early phase of salamander limb regeneration-wound healing, cellular dedifferentiation and blastemal formation-will reveal therapeutic approaches for tissue regeneration in humans. Here we describe a unique transcriptional fingerprint of regenerating limb tissue in the Mexican axolotl (Ambystoma mexicanum) that is indicative of cellular reprogramming of differentiated cells to a germline-like state. Two genes that are required for self-renewal of germ cells in mice and flies, Piwi-like 1 (PL1) and Pi...
Subjects
free text keywords: Molecular Biology, Cell Biology, Developmental Biology, Article
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publication . Article . Other literature type . 2012

Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl

Zhu, Wei; Pao, Gerald M.; Satoh, Akira; Cummings, Gillian; Monaghan, James R.; Harkins, Timothy T.; Bryant, Susan V.; Randal Voss, S.; Gardiner, David M.; Hunter, Tony;