Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521

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Nakano, Masayuki; Yahiro, Kinnosuke; Yamasaki, Eiki; Kurazono, Hisao; Akada, Junko; Yamaoka, Yoshio; Niidome, Takuro; Hatakeyama, Masanori; Suzuki, Hidekazu; Yamamoto, Taro; Moss, Joel; Isomoto, Hajime; Hirayama, Toshiya;
  • Publisher: The Company of Biologists Ltd
  • Journal: Disease Models & Mechanisms, volume 9, issue 12, pages 1,473-1,481 (issn: 1754-8403, eissn: 1754-8411)
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  • Identifiers: doi: 10.1242/dmm.025361, pmc: PMC5200893
  • Subject: Helicobacter pylori | RB1-214 | R | Pathology | Research Article | CagA | Medicine | VacA
    mesheuropmc: bacteria | bacterial infections and mycoses | digestive system diseases

ABSTRACT Helicobacter pylori, a major cause of gastroduodenal diseases, produces vacuolating cytotoxin (VacA) and cytotoxin-associated gene A (CagA), which seem to be involved in virulence. VacA exhibits pleiotropic actions in gastroduodenal disorders via its specific r... View more
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