Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function

Article, Review English OPEN
Kosan, Christian; Godmann, Maren;
(2015)

All hematopoiesis cells develop from multipotent progenitor cells. Hematopoietic stem cells (HSC) have the ability to develop into all blood lineages but also maintain their stemness. Different molecular mechanisms have been identified that are crucial for regulating qu... View more
  • References (155)
    155 references, page 1 of 16

    Doulatov, S., Notta, F., Laurenti, E., Dick, J. E.. Hematopoiesis: a human perspective. Cell Stem Cell. 2012; 10 (2): 120-136

    Wilson, A., Laurenti, E., Trumpp, A.. Balancing dormant and self-renewing hematopoietic stem cells. Current Opinion in Genetics and Development. 2009; 19 (5): 461-468

    Rossi, D. J., Seita, J., Czechowicz, A., Bhattacharya, D., Bryder, D., Weissman, I. L.. Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging. Cell Cycle. 2007; 6 (19): 2371-2376

    Foudi, A., Hochedlinger, K., Van Buren, D., Schindler, J. W., Jaenisch, R., Carey, V., Hock, H.. Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nature Biotechnology. 2009; 27 (1): 84-90

    Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., Lió, P., MacDonald, H. R., Trumpp, A.. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell. 2008; 135 (6): 1118-1129

    Takizawa, H., Regoes, R. R., Boddupalli, C. S., Bonhoeffer, S., Manz, M. G.. Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation. The Journal of Experimental Medicine. 2011; 208 (2): 273-284

    Seita, J., Weissman, I. L.. Hematopoietic stem cell: self-renewal versus differentiation. Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 2010; 2 (6): 640-653

    Mohrin, M., Bourke, E., Alexander, D., Warr, M. R., Barry-Holson, K., Le Beau, M. M., Morrison, C. G., Passegué, E.. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell. 2010; 7 (2): 174-185

    Trumpp, A., Essers, M., Wilson, A.. Awakening dormant haematopoietic stem cells. Nature Reviews Immunology. 2010; 10 (3): 201-209

    Morrison, S. J., Weissman, I. L.. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity. 1994; 1 (8): 661-673

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