Progesterone in breast cancer angiogenesis

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Botelho, M.C. ; Soares, R. ; Alves, H. (2015)
  • Publisher: SM Group
  • Subject: Angiogenesis | Progesterone | VEGF | Breast Cancer | Article
    mesheuropmc: skin and connective tissue diseases

The involvement of steroid hormones in breast carcinogenesis is well established. Recent evidence suggests that angiogenesis can be regulated by hormones. Both oestrogen and progesterone have been implicated in the angiogenic process of hormone-dependent cancers, such as breast cancer. Vascular Endothelial Growth Factor (VEGF) is a growth factor involved in angiogenesis in breast cancer that is up-regulated by estrogens. In our study we evaluated the role of progesterone in the expression of this angiogenic growth factor commonly up-regulated in breast cancer. Our findings indicate that progesterone activates an angiogenic pathway involving VEGF stimulation. The elucidation of specific angiogenic pathways promoted by progesterone can raise new therapeutic targets at least in a subset of breast cancers responsive to progesterone.
  • References (16)
    16 references, page 1 of 2

    1. Marinho AF, Botelho M, Schmitt FC. Evaluation of Numerical Abnormalities of Chromosomes 1 and 17 in Proliferative Epithelial Breast Lesions Using Fluorescence in situ Hybridization. Pathol Res Pract. 2000; 196:227-233. [PubMed: 10782466]

    2. Soares R, Pereira MB, Silva C, Ferro J, Wagner R, Schmitt FC. Expression of TGF-α and EGFR in breast cancer and its relation to angiogenesis. Breast J. 2000; 6:171-177. [PubMed: 11348360]

    3. Botelho M, Amendoeira I, Diamond J, Dias S, Schmitt F. Breast tumors induce the recruitment of AC133+KDR+ endothelial precursor cells mobilized by plasma vascular endothelial growth factor. Breast Cancer Research. 2005; 7:1-1. DOI:10.1186/bcr1187. [PubMed: 15642174]

    4. Fu XD, Russo E, Zullino S, Genazzani AR, Simoncini T. Sex steroids and breast cancer metastasis. Horm Mol Biol Clin Investig. 2010; 3:383-389. doi: 10.1515/HMBCI.2010.058.

    5. Fraser IS. Regulating menstrual bleeding. A prime function of progesterone. J Reprod Med. 1999; 44(2 suppl):158-164. [PubMed: 11392026]

    6. Classen-Linke I, Alfer J, Krusche CA, Chwalisz K, Rath W, Beier HM. Progestins, progesterone receptor modulators, and progesterone antagonists change VEGF release of endometrial cells in culture. Steroids. 2000; 65:763-771. [PubMed: 11108887]

    7. Soares R, Guerreiro S, Botelho M. Elucidating progesterone effects in breast cancer: cross talk with PDGF signaling pathway in smooth muscle cell. J Cell Biochem. 2007; 100:174-183. [PubMed: 16888808]

    8. Hyder SM, Liang Y, Wu J, Welbern V. Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells. Endocr Relat Cancer. 2009; 16:809-817. doi: 10.1677/ ERC-08-0311. [PubMed: 19570906]

    9. Carroll CE, Liang Y, Benakanakere I, Besch-Williford C, Hyder SM. The anticancer agent YC-1 suppresses progestin-stimulated VEGF in breast cancer cells and arrests breast tumor development. Int J Oncol. 2013; 42:179-187. doi: 10.3892/ijo.2012.1675. [PubMed: 23123638]

    10. Moens S, Goveia J, Stapor PC, Cantelmo AR, Carmeliet P. The multifaceted activity of VEGF in angiogenesis - Implications for therapy responses. Cytokine Growth Factor Rev. 2014; 25:473- 482. doi: 10.1016/j.cytogfr.2014.07.009. [PubMed: 25169850]

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