Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia

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Pitarresi, Jason R.; Liu, Xin; Sharma, Sudarshana M.; Cuitiño, Maria C.; Kladney, Raleigh D.; Mace, Thomas A.; Donohue, Sydney; Nayak, Sunayana G.; Qu, Chunjing; Lee, James; Woelke, Sarah A.; Trela, Stefan; LaPak, Kyle; Yu, Lianbo; McElroy, Joseph; Rosol, Thomas J.; Shakya, Reena; Ludwig, Thomas; Lesinski, Gregory B.; Fernandez, Soledad A.; Konieczny, Stephen F.; Leone, Gustavo; Wu, Jinghai; Ostrowski, Michael C.;
  • Publisher: Elsevier BV
  • Journal: Neoplasia,volume 18,issue 9,pages541-552 (issn: 1476-5586, eissn: 1522-8002)
  • Related identifiers: doi: 10.1016/j.neo.2016.07.006
  • Subject: RC254-282 | Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Preclinical studies have suggested that the pancreatic tumor microenvironment both inhibits and promotes tumor development and growth. Here we establish the role of stromal fibroblasts during acinar-to-ductal metaplasia (ADM), an initiating event in pancreatic cancer fo... View more
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