SRY-box-containing Gene 2 Regulation of Nuclear Receptor Tailless (Tlx) Transcription in Adult Neural Stem Cells
Shimozaki, Koji; Zhang, Chun-Li; Suh, Hoonkyo; Denli, Ahmet M.; Evans, Ronald M.; Gage, Fred H.;
- Publisher: American Society for Biochemistry and Molecular Biology Inc.
- Journal: Journal of Biological Chemistry,volume 287,issue 8,pages5,969-5,978 (issn: 0021-9258)
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- Subject: transcription factor | Luciferase reporter assays | Transcription | Transcription factors | protein function | transcription factor Sox2 | Upstream region; Wild types | negative feedback | protein DNA binding | protein structure | gene product | mouse | enzyme activity | protein targeting | female | Molecular levels | protein expression | binding site | Adult neurogenesis | Stem cells | protein protein interaction | Negative feedback loop | rat | Genes | animal cell | nuclear receptor tailless transcription factor | Nucleic acids | article | gene expression regulation | cell renewal | Gene Regulation | nonhuman | wild type | DNA-binding | nerve cell network | unclassified drug | neural stem cell | transcription initiation | nervous system development | Nuclear receptors | Transcriptional activity | Tlx gene | priority journal | complex formation | Molecular networks | Transcriptional activation domain | gene structure | Signaling pathways | controlled studymesheuropmc: biological phenomena, cell phenomena, and immunity | embryonic structures | fungi
Adult neurogenesis is maintained by self-renewable neural stem cells (NSCs). Their activity is regulated by multiple signaling pathways and key transcription factors. However, it has been unclear whether these factors interplay with each other at the molecular level. He... View more
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