Mesenchymal Stem Cell Therapy in Diabetes Mellitus: Progress and Challenges

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El-Badri, Nagwa; Ghoneim, Mohamed A.;

Advanced type 2 diabetes mellitus is associated with significant morbidity and mortality due to cardiovascular, nervous, and renal complications. Attempts to cure diabetes mellitus using islet transplantation have been successful in providing a source for insulin secret... View more
  • References (71)
    71 references, page 1 of 8

    WHO Report, null. Burden: mortality, morbidity and risk factors—WHO report. Global Status Report on NCDs. 2010

    Koro, C. E., Bowlin, S. J., Bourgeois, N., Fedder, D. O.. Glycemic control from 1988 to 2000 among U.S. adults diagnosed with type 2 diabetes: a preliminary report. Diabetes Care. 2004; 27 (1): 17-20

    Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., Kneteman, N. M., Rajotte, R. V.. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. The New England Journal of Medicine. 2000; 343 (4): 230-238

    Ryan, E. A., Paty, B. W., Senior, P. A., Bigam, D., Alfadhli, E., Kneteman, N. M., Lakey, J. R. T., Shapiro, A. M. J.. Five-year follow-up after clinical islet transplantation. Diabetes. 2005; 54 (7): 2060-2069

    Bellin, M. D., Barton, F. B., Heitman, A., Harmon, J. V. ., Kandaswamy, R., Balamurugan, A. N., Sutherland, D. E., Alejandro, R., Hering, B. J.. Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes. American Journal of Transplantation. 2012; 12 (6): 1576-1583

    Lumelsky, N., Blondel, O., Laeng, P., Velasco, I., Ravin, R., McKay, R.. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science. 2001; 292 (5520): 1389-1394

    Jiang, Y., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., Du, J., Aldrich, S., Lisberg, A., Low, W. C., Lergaespada, D. A., Verfaillie, C. M.. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002; 418 (6893): 41-49

    Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., Agulnick, A. D., D'Amour, K. A., Carpenter, M. K., Baetge, E. E.. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nature Biotechnology. 2008; 26 (4): 443-452

    Jiang, W., Shi, Y., Zhao, D.. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Research. 2007; 17: 333-344

    Jeon, K., Lim, H., Kim, J. H.. Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model. Stem Cells Development. 2012; 21 (14): 2642-2655

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