JAG: A Computational Tool to Evaluate the Role of Gene-Sets in Complex Traits.

Article, Other literature type English OPEN
Lips, E.S. ; Kooyman, M. ; de Leeuw, C.A. ; Posthuma, D. (2015)
  • Publisher: Multidisciplinary Digital Publishing Institute
  • Journal: Genes, volume 6, issue 2, pages 238-251 (issn: 2073-4425, eissn: 2073-4425)
  • Related identifiers: pmc: PMC4488663, doi: 10.3390/genes6020238
  • Subject: gene-set analysis | GWAS | QH426-470 | Genetics | genetic association | biological pathway | pathway analysis | Article

Gene-set analysis has been proposed as a powerful tool to deal with the highly polygenic architecture of complex traits, as well as with the small effect sizes typically found in GWAS studies for complex traits. We developed a tool, Joint Association of Genetic variants... View more
  • References (31)
    31 references, page 1 of 4

    Hum. Genet 2012, 90, 7-24.

    2. Sullivan, P.F.; Daly, M.J.; O'Donovan, M. Genetic architectures of psychiatric disorders: The emerging picture and its implications. Nat. Rev. Genet 2012, 13, 537-551.

    3. Franke, A.; McGovern, D.P.; Barrett, J.C.; Wang, K.; Radford-Smith, G.L.; Ahmad, T.; Lees, C.W.; Balschun, T.; Lee, J.; Roberts, R.; et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet 2010, 42, 1118-1125.

    4. Voight, B.F.; Scott, L.J.; Steinthorsdottir, V.; Morris, A.P.; Dina, C.; Welch, R.P.; Zeggini, E.; Huth, C.; Aulchenko, Y.S.; Thorleifsson, G.; et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat. Genet 2010, 42, 579-589.

    5. Rietveld, C.A.; Medland, S.E.; Derringer, J.; Yang, J.; Esko, T.; Martin, N.W.; Westra, H.J.; Shakhbazov, K.; Abellaoui, A.; Agrawal, A.; et al. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science 2013, 340, 1467-1471.

    6. Ripke, S.; O'Dushlaine, C.; Chambert, K.; Moran, J.L.; Kahler, A.K.; Akterin, S.; Bergen, S.E.; Collins, A.L.; Crowley, J.J.; Fromer, M.; et al. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat. Genet 2013, 45, 1150-1159.

    7. Speliotes, E.K.; Willer, C.J.; Berndt, S.I.; Monda, K.L.; Thorleifsson, G.; Jackson, A.U.; Lango Allen, H.; Lindgren, C.M.; Luan, J.; Mägi, R.; et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet 2010, 42, 937-948.

    8. Lango Allen, H.; Estrada, K.; Lettre, G.; Berndt, S.I.; Weedon, M.N.; Rivadeneira, F.; Willer, C.J.; Jackson, A.U.; Vedantam, S.; Raychaudhuri, S.; et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010, 467, 832-838.

    9. International Schizophrenia Consortium; Purcell, S.M.; Wray, N.R.; Stone, J.L.; Visscher, P.M.; O'Donovan, M.C.; Sullivan, P.M.; Sklar, P. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460, 748-752.

    10. Visscher, P.M. Sizing up human height variation. Nat. Genet 2008, 40, 489-490.

  • Related Research Results (2)
  • Metrics
    views in OpenAIRE
    views in local repository
    downloads in local repository
Share - Bookmark