Glucagon-like peptide-1 (GLP-1) raises blood-brain glucose transfer capacity and hexokinase activity in human brain

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Gejl, Michael; Lerche, Susanne; Egefjord, Lærke; Brock, Birgitte; Møller, Niels; Vang, Kim; Rodell, Anders B.; Bibby, Bo M.; Holst, Jens J.; Rungby, Jørgen; Gjedde, Albert;
(2013)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Neuroenergetics,volume 5,pagesJensen , M G , Lerche , S , Egefjord , L , Brock , B , Møller , N , Vang , K , Rodell , A B , Bibby , B M , Holst , J J , Rungby , J & Gjedde , A 2013 , ' Glucagon-like peptide-1 (GLP-1) raises blood-brain glucose transfer capacity and hexokinase activity in human brain ' Frontiers in Neuroenergetics , vol. 5 , pp. 2 . https://doi.org/10.3389/fnene.2013.00002-Jensen , M G , Lerche , S , Egefjord , L , Brock , B , Møller , N , Vang , K , Rodell , A B , Bibby , B M , Holst , J J , Rungby , J & Gjedde , A 2013 , ' Glucagon-like peptide-1 (GLP-1) raises blood-brain glucose transfer capacity and hexokinase activity in human brain ' Frontiers in Neuroenergetics , vol. 5 , pp. 2 . https://doi.org/10.3389/fnene.2013.00002 (issn: 1662-6427, eissn: 1662-6427)
  • Related identifiers: pmc: PMC3608902, doi: 10.3389/fnene.2013.00002
  • Subject: blood-brain barrier | Michaelis-Menten | hyperglycemia | cerebral metabolic rate for glucose | cerebral glucose transport | Neuroscience | glucagon-like peptide -1 | hypoglycemia | Original Research Article

In hyperglycemia, glucagon-like peptide-1 (GLP-1) lowers brain glucose concentration together with increased net blood-brain clearance and brain metabolism, but it is not known whether this effect depends on the prevailing plasma glucose (PG) concentration. In hypoglyce... View more
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